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Published on: February 15, 2022
Masked hypertension: evidence of the need to treat
Gbenga Ogedegbe1, Charles Agyemang, Joseph E Ravenell
1Center for Healthful Behavior Change, Division of General Internal Medicine, New York University School of Medicine, 423 East 23rd Street #15-168N, New York, NY 10010, USA. Olugbenga.Ogedegbe@nyumc.org
Insights
Masked hypertension, diagnosed using accurate home monitoring, significantly increases cardiovascular risks. Early identification and treatment are crucial for reducing patient morbidity and mortality.
Area of Science:
- Cardiology
- Hypertension Management
- Preventive Medicine
Background:
- Masked hypertension poses significant cardiovascular risks, comparable to sustained hypertension.
- Home blood pressure monitoring (HBPM) now offers accurate diagnosis, similar to ambulatory blood pressure monitoring (ABPM).
- Target organ damage is well-documented in patients with masked hypertension.
Purpose of the Study:
- To review the cardiovascular prognosis of masked hypertension versus sustained hypertension.
- To examine the impact of masked hypertension on target organ damage.
- To propose a treatment algorithm for masked hypertension and discuss implementation challenges.
Main Methods:
- Review of clinic-based and population-based studies.
- Analysis of evidence on cardiovascular morbidity and mortality.
- Evaluation of the relationship between masked hypertension and target organ damage.
Main Results:
- Masked hypertension is associated with increased cardiovascular morbidity and mortality.
- Evidence supports blood pressure treatment to reduce cardiovascular events.
- Active identification and treatment of masked hypertension are warranted.
Conclusions:
- Masked hypertension requires active identification and management.
- Treatment strategies for masked hypertension should align with those for sustained hypertension.
- Careful consideration of potential pitfalls is necessary for effective implementation.
Abstract:
The diagnosis of masked hypertension has been made easier with the widespread availability of home blood pressure monitoring devices with levels of accuracy comparable to ambulatory blood pressure monitoring. The negative impact of masked hypertension on cardiovascular morbidity and mortality is evidenced by numerous well-designed clinic-based and population-based studies. The relationship of masked hypertension and target organ damage is also well documented. These two factors, combined with the robust evidence of reduced cardiovascular morbidity and mortality achieved with blood pressure treatment, makes the argument for actively identifying patients with masked hypertension and prescribing treatment similar to that for patients with sustained hypertension. In this paper, we review the evidence for the cardiovascular prognosis of masked hypertension compared with sustained hypertension, we review its impact on target organ damage, we propose an algorithm for the treatment of patients with masked hypertension, and we point out the pitfalls in adopting such an approach.
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