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Evaluation of left ventricular hypertrophy in patients requiring permanent pacing

Alexandros Alexopoulos1, Anastasia Perpinia, Nikolaos Michelakakis

  • 1Department of Cardiology, Athens General Hospital, Mesogeion Avenue, 154, 15669 Athens, Greece. aalexop@upatras.gr

Therapeutic Advances in Cardiovascular Disease
|August 11, 2010
PubMed

Insights

Hypertension is linked to left ventricular hypertrophy, a condition associated with complete atrioventricular block (AVB). This study found a significant association between AVB and abnormal echocardiographic indexes, supporting the hypothesis.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology

Background:

  • Hypertension can cause left ventricular hypertrophy (LVH), fibrosis, and conduction system degeneration.
  • LVH and conduction abnormalities may necessitate permanent pacemaker implantation.

Purpose of the Study:

  • To investigate the association between left ventricular hypertrophy and specific arrhythmias.
  • To explore the link between LVH and complete atrioventricular block (AVB) and symptomatic sick sinus syndrome (SSS).

Main Methods:

  • Echocardiography was used to assess relative wall thickness (RWT) and left ventricular mass (LVM) in 130 patients with complete AVB, 130 with SSS, and 45 controls.
  • Patients with complete AVB or symptomatic SSS had received permanent pacemakers.

Main Results:

  • A significant association was found between complete AVB and abnormal echocardiographic indexes of left ventricular hypertrophy.
  • The majority of patients diagnosed with complete AVB had a history of hypertension.

Conclusions:

  • The findings support the hypothesis that complete AVB is associated with left ventricular hypertrophy.
  • Hypertension is a likely contributing factor to the development of complete AVB in patients with LVH.
Abstract

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