[Intestinal permeability disorders in children]

Area of Science:

• Gastroenterology
• Immunology
• Pediatrics

Background:

• The intestinal lining exhibits permeability, allowing passage of molecules and macromolecules.
• Intestinal permeability is influenced by molecular size and mucosal status.
• This property is crucial for nutrient absorption and barrier function.

Purpose of the Study:

• To evaluate the integrity of the small intestine using inert markers.
• To investigate the diagnostic utility of intestinal permeability tests.
• To assess the role of intestinal permeability in pediatric enteropathies and intolerances.

Main Methods:

• Utilizing inert markers of various molecular weights, including polyethylene glycols (PEG).
• Employing monosaccharide sugars (mannitol, rhamnose) and disaccharide sugars (lactulose, cellobiose).
• Assessing intestinal permeability through marker passage into circulation, potentially alongside food provocation tests.

Main Results:

• Intestinal permeability testing aids in detecting conditions such as celiac disease and Crohn's disease.
• The method is repeatable and valuable for diagnosing food intolerances in children.
• Abnormal permeability can indicate enteropathy related to cow's milk proteins, atopic dermatitis, and irritable colon.

Conclusions:

• Inert marker assessment of intestinal permeability is a valuable tool for evaluating small intestine integrity.
• This technique supports the diagnosis of various gastrointestinal and allergic conditions in both adults and children.
• Repeated measurements are feasible, particularly for monitoring responses during diagnostic food challenges.