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[Intestinal permeability disorders in children].

C Dupont1, E Barau, P Molkhou

  • 1Hôpital Saint Vincent de Paul, Paris.

Allergie Et Immunologie
|March 1, 1991
PubMed
Summary
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Intestinal permeability, or "porosity," allows molecules to cross the gut wall. This can be assessed using inert markers to evaluate small intestine integrity and diagnose conditions like celiac disease.

Area of Science:

  • Gastroenterology
  • Immunology
  • Pediatrics

Background:

  • The intestinal lining exhibits permeability, allowing passage of molecules and macromolecules.
  • Intestinal permeability is influenced by molecular size and mucosal status.
  • This property is crucial for nutrient absorption and barrier function.

Purpose of the Study:

  • To evaluate the integrity of the small intestine using inert markers.
  • To investigate the diagnostic utility of intestinal permeability tests.
  • To assess the role of intestinal permeability in pediatric enteropathies and intolerances.

Main Methods:

  • Utilizing inert markers of various molecular weights, including polyethylene glycols (PEG).
  • Employing monosaccharide sugars (mannitol, rhamnose) and disaccharide sugars (lactulose, cellobiose).

Related Experiment Videos

  • Assessing intestinal permeability through marker passage into circulation, potentially alongside food provocation tests.

    • Main Results:

    • Intestinal permeability testing aids in detecting conditions such as celiac disease and Crohn's disease.
    • The method is repeatable and valuable for diagnosing food intolerances in children.
    • Abnormal permeability can indicate enteropathy related to cow's milk proteins, atopic dermatitis, and irritable colon.

    Conclusions:

    • Inert marker assessment of intestinal permeability is a valuable tool for evaluating small intestine integrity.
    • This technique supports the diagnosis of various gastrointestinal and allergic conditions in both adults and children.
    • Repeated measurements are feasible, particularly for monitoring responses during diagnostic food challenges.