Effect of hydrophobic interaction cooperating with double Lewis acid activation in a zinc(II) phosphodiesterase mimic
Meng Zhao1, Li Zhang, Huo-Yan Chen
1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
Chemical Communications (Cambridge, England)
|August 11, 2010
Abstract:
The novel dinuclear Zn(ii) complex (1) containing a beta-CD dimer could accelerate BNPP (a DNA substitute) hydrolysis more efficiently than catalyze HPNP (a RNA substitute) transesterification with different mechanisms involved; the beta-CDs played remarkably different roles.
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