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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Hand hygiene01:23

Hand hygiene

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Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
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Related Experiment Video

Updated: Jun 10, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Preoperative methicillin-resistant Staphylococcus aureus screening in Mohs surgery appears to decrease postoperative

Katharine B Cordova1, Nicole Grenier, Kyung Hee Chang

  • 1Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|August 12, 2010
PubMed
Summary
This summary is machine-generated.

A new protocol significantly reduced methicillin-resistant Staphylococcus aureus (MRSA) wound infections after Mohs surgery. Preoperative screening and decontamination lowered infection rates, suggesting a promising approach for patient safety.

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Last Updated: Jun 10, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Dermatology
  • Infectious Disease Control
  • Surgical Safety

Background:

  • Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) increases the risk of postoperative wound infections.
  • MRSA infections pose a significant threat to patient outcomes following surgical procedures.

Purpose of the Study:

  • To evaluate the effectiveness of a decontamination and prophylaxis protocol in preventing postoperative MRSA wound infections.
  • To assess the impact of MRSA screening on infection rates in patients undergoing Mohs surgery.

Main Methods:

  • Retrospective review of wound cultures before and after implementing a screening and decontamination protocol.
  • Preoperative nasal MRSA screening followed by intranasal mupirocin and oral trimethoprim-sulfamethoxazole for identified carriers.

Main Results:

  • Prior to the protocol, 0.3% of 3,633 Mohs cases resulted in MRSA wound infections.
  • After protocol implementation, none of the 22 treated MRSA carriers developed postoperative wound infections.
  • One untreated MRSA carrier developed a wound infection, highlighting the protocol's efficacy.

Conclusions:

  • Preoperative MRSA screening and decontamination protocols appear effective in reducing postoperative wound infections after Mohs surgery.
  • Further controlled studies are needed to confirm clinical and cost-effectiveness before widespread adoption.
  • The findings suggest a potential strategy for enhancing surgical site infection prevention.