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Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
Published on: October 29, 2014
Acute bacterial meningitis in children
D M Olanrewaju1, O Olusanya, A A Laditan
1College of Health Sciences, Ogun State University, Sagamu, Nigeria.
Insights
Childhood pyogenic meningitis is a significant health issue, with Streptococcus pneumoniae as the most common cause. Early treatment is crucial to reduce mortality and morbidity in affected children.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- Pyogenic meningitis poses a significant health challenge in childhood.
- This study examines pyogenic meningitis cases in a Nigerian teaching hospital.
Purpose of the Study:
- To analyze the epidemiology and outcomes of pyogenic meningitis in children.
- To identify key prognostic factors influencing mortality and morbidity.
Main Methods:
- Retrospective study of 48 pediatric patients admitted between January 1986 and December 1987.
- Data collected on patient demographics, causative organisms, treatment intervals, and outcomes.
Main Results:
- Meningitis accounted for 2.8% of pediatric admissions.
- Streptococcus pneumoniae was the predominant pathogen (67.5%).
- Mortality rate was 26.1%, with 23.5% of survivors experiencing significant morbidity.
Conclusions:
- Childhood pyogenic meningitis is an important community health problem.
- Prognostic factors include coma, persistent convulsions, low CSF glucose, low serum sodium, and delayed treatment.
- Timely intervention is critical for improving outcomes in pediatric meningitis.
Abstract:
A retrospective study of 48 children with pyogenic meningitis who were admitted between January 1986 and December, 1987 at the Ogun State University Teaching Hospital, Sagamu has shown that childhood meningitis is an important health problem in the community as it accounted for 2.8% of 1,724 admissions into the paediatric ward. The ages of the patients ranged from three weeks to twelve years with a mean of 2 1/2 years. The commonest causative organism was Streptococcus pneumoniae which accounted for 67.5% of all isolates. The mortality rate was 26.1% while significant morbidity occurred in 23.5% of survivors. Important prognostic factors included the presence of coma or persistent convulsions, low CSF glucose and low serum sodium levels as well as the interval between symptoms and treatment.
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