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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation
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Functional magnetic resonance imaging using RASER.

Ute Goerke1, Michael Garwood, Kamil Ugurbil

  • 1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA. ute@cmrr.umn.edu

Neuroimage
|August 12, 2010
PubMed
Summary
This summary is machine-generated.

A new functional magnetic resonance imaging (fMRI) technique called RASER (rapid acquisition by sequential excitation and refocusing) overcomes limitations of conventional methods. This allows for clearer brain imaging in previously inaccessible regions, improving neuronal activity studies.

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Area of Science:

  • Neuroimaging
  • Magnetic Resonance Imaging
  • Brain Activity Mapping

Background:

  • Functional magnetic resonance imaging (fMRI) is a key tool for studying brain activity.
  • Conventional fMRI is limited in brain regions near air cavities due to magnetic field inhomogeneities.
  • These limitations restrict the study of neuronal activity in critical brain areas.

Purpose of the Study:

  • To introduce and validate a novel pulse sequence, RASER (rapid acquisition by sequential excitation and refocusing).
  • To demonstrate RASER's ability to eliminate sensitivity to magnetic field inhomogeneities.
  • To enable fMRI in brain regions previously inaccessible to conventional techniques.

Main Methods:

  • Development and application of the RASER pulse sequence.
  • Acquisition of purely and perfectly T(2) weighted signals, avoiding T(2)*-effects.
  • Quantification of the RASER-based fMRI response.

Main Results:

  • RASER successfully eliminates sensitivity to magnetic field inhomogeneities.
  • RASER-acquired signals are purely T(2) weighted, enhancing specificity.
  • RASER provides fMRI in challenging regions like the orbitofrontal cortex with less noisy time series.

Conclusions:

  • RASER significantly advances fMRI capabilities by overcoming conventional limitations.
  • The technique offers improved specificity and reduced noise for brain activity mapping.
  • RASER opens new possibilities for studying neuronal activity in previously inaccessible brain areas.