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Hyperhomocysteinemia prevalence among patients with venous thromboembolism

Nurdan Köktürk1, Asiye Kanbay, Müge Aydoğdu

  • 1Department of Pulmonary Medicine, Gazi University School of Medicine, Besevler, Ankara, Turkey. kokturk.nurdan@gmail.com

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|August 12, 2010
PubMed

Insights

Elevated plasma homocysteine levels are common in patients with venous thromboembolism (VTE), indicating hyperhomocysteinemia is a significant risk factor. Monitoring and managing this condition may help prevent VTE recurrence.

Area of Science:

  • Clinical Medicine
  • Hematology
  • Biochemistry

Background:

  • Venous thromboembolism (VTE) is a significant health concern.
  • Plasma total homocysteine levels are implicated as a potential risk factor for VTE.
  • Understanding the prevalence and impact of hyperhomocysteinemia in VTE is crucial for patient management.

Purpose of the Study:

  • To evaluate plasma total homocysteine levels in patients diagnosed with VTE.
  • To investigate the influence of various risk factors on plasma homocysteine concentrations.
  • To determine the association between hyperhomocysteinemia and the risk of VTE.

Main Methods:

  • A case-control study involving 93 VTE patients and 37 controls.
  • Measurement of plasma total homocysteine levels.
  • Analysis of factors affecting plasma homocysteine, including vitamin B12 and folate levels.
  • Regression analysis to assess the risk associated with hyperhomocysteinemia.

Main Results:

  • Plasma homocysteine levels were significantly higher in VTE patients compared to controls, irrespective of vitamin B12 and folate status.
  • The prevalence of hyperhomocysteinemia among VTE patients was 63%.
  • Patients with pulmonary embolism (PE) exhibited higher homocysteine levels than those with deep venous thrombosis (DVT).
  • Hyperhomocysteinemia was associated with a 4.8-fold increased risk of VTE.

Conclusions:

  • Hyperhomocysteinemia is a prevalent and potentially modifiable risk factor for VTE.
  • Screening for and managing hyperhomocysteinemia should be considered in VTE patients.
  • Monitoring secondary causes, such as vitamin B12 deficiency, is important for preventing VTE recurrence.

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