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Effect of black-currant extract on negative lens-induced ocular growth in chicks
Hiroyuki Iida1, Yuko Nakamura, Hitoshi Matsumoto
1Food and Health R&D Laboratories, Meiji Seika Kaisha Ltd., Sakado, Japan. hiroyuki_iida@meiji.co.jp
Aim:
To evaluate the effects of orally administered black-currant (BC) extract on the enlargement of globe component dimensions induced in chicks by wearing negative lenses.
Methods:
Negative lenses (-8 D) were worn on the right eyes by 8-day-old chicks, and their fellow eyes acted as controls. BC extract and distilled water (vehicle control) were orally administered once a day for 3 days. To confirm the effect of BC anthocyanins (BCAs), they were intravenously administered once a day for 3 days. Dimensions of globe components of right eyes and fellow eyes were measured with an A-scan ultrasound instrument on the third day (day 4) after placement of the negative lenses.
Results:
Orally administered BC extract significantly inhibited enlargement of vitreous-chamber depth, axial and ocular lengths in a dose-dependent manner when compared to controls. Intravenously administered BCAs also inhibited elongation of vitreous-chamber depth and axial length when compared to controls.
Conclusions:
This is the first evidence that BC extract and BCAs could inhibit enlargement of globe component dimensions in a negative lens-induced chick myopia model.
