Related Experiment Video
Updated: Jun 10, 2026

06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Metachronous colorectal cancer
M G Pramateftakis1, P Hatzigianni, D Kanellos
14th Surgical Department, Aristotle University, Thessaloniki, Greece. mpramateftakis@hotmail.com
Techniques in Coloproctology
|August 12, 2010
Summary
Metachronous colorectal cancer is a rare but significant risk. Regular colonoscopies after initial treatment are crucial for early detection in colorectal cancer survivors.
Area of Science:
- Gastroenterology
- Oncology
- Surgical Oncology
Background:
- Colorectal cancer (CRC) management requires long-term surveillance.
- Understanding the incidence and timing of metachronous CRC is vital for patient outcomes.
Purpose of the Study:
- To report on patients who developed metachronous colorectal cancer.
- To highlight the importance of ongoing surveillance in CRC patients.
Main Methods:
- Retrospective analysis of 670 patients treated for colorectal cancer between 1990 and 2009.
- Identification of cases with metachronous secondary colorectal cancer.
Main Results:
- Four patients (0.6%) developed metachronous colorectal cancer.
- The interval between the initial and secondary cancer ranged from 28 months to 22 years (mean 146 months).
Conclusions:
- Metachronous colorectal cancer represents a notable risk for patients with a history of CRC.
- Postoperative colonoscopic surveillance is essential for all patients treated for colorectal cancer.
Related Concept Videos
Diverticular Disease of the Colon
Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

