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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
Suggestive synchronous triple squamous cell carcinoma of the lung in the same lobe
Riki Okita1, Katsuhiko Shimizu, Takeshi Mimura
1Department of General Thoracic Surgery, Hiroshima University Hospital, Hiroshima, Japan. riki0716okita@yahoo.co.jp
Abstract:
We report a case of suggestive synchronous triple squamous cell carcinoma (Sq) of the lung that occurred in the same lobe. Under a clinical diagnosis of triple lung cancer, lobectomy was performed. Pathological examination revealed two well-differentiated Sq and one poorly differentiated Sq. The analysis of epidermal growth factor receptor-tyrosine kinase mutations showed no mutation in each tumor. However, pathological findings and the positive rate of immunochemical reaction of p53 and Ki-67 were different in each tumor.
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