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Related Concept Videos

Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Sputum Studies I: Gram Stain, cytology, and Acid-fast smear and culture01:26

Sputum Studies I: Gram Stain, cytology, and Acid-fast smear and culture

Sputum studies are a critical part of diagnosing and treating numerous respiratory conditions. These studies involve obtaining sputum samples for analysis to identify pathogenic organisms and assess the presence of abnormal cells indicative of malignant conditions. This lesson will delve into three fundamental sputum studies: Gram Stain, Cytology, and Acid-fast Smear and Culture.
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...

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Related Experiment Video

Updated: Jun 10, 2026

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
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Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

Published on: March 23, 2014

Study of leprosy in children.

A G Rao1

  • 1Department of Dermatology, Gandhi Medical College, Secundrerabad, AP, India. dr_a_g_rao@yahoo.co.in

Indian Journal of Leprosy
|August 14, 2010
PubMed
Summary

Childhood leprosy, a significant public health concern, was studied in 32 children over 4 years. The findings highlight disease patterns and effective control in pediatric leprosy cases.

Area of Science:

  • Medical Science
  • Public Health
  • Pediatrics

Background:

  • Leprosy remains a public health challenge, particularly in developing nations.
  • Childhood leprosy incidence reflects community transmission and control program effectiveness.

Purpose of the Study:

  • To analyze the characteristics and clinical presentation of childhood leprosy.
  • To assess the incidence and common types of leprosy in children.

Main Methods:

  • A 4-year retrospective study of 280 leprosy patients at Gandhi Hospital.
  • Inclusion of 32 diagnosed childhood leprosy cases for detailed analysis.
  • Clinical examination, slit-skin smears, and biopsies for clinico-pathological correlation.

Main Results:

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

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Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

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DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)
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DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

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  • Childhood leprosy accounted for 11.43% of all cases, with a higher incidence in boys.
  • Hypopigmented anesthetic patches were the most common presentation.
  • Hansen's BT was the predominant type, affecting extremities; slit-skin smears were positive in 25%.

Conclusions:

  • Childhood leprosy is a key indicator of disease transmission and control efficacy.
  • Early diagnosis and treatment in children can lead to better outcomes with fewer deformities.