Related Experiment Videos
Cycloleonurinin, a cyclic peptide from Leonuri Fructus
K Kinoshita1, J Tanaka, K Kuroda
1Meiji College of Pharmacy, Tokyo, Japan.
Chemical & Pharmaceutical Bulletin
|March 1, 1991
Summary
Researchers isolated a cyclic peptide from Leonuri Fructus. Mass spectroscopy and protein sequencing determined the twelve amino acid residue sequence, advancing peptide research.
Area of Science:
- Natural Product Chemistry
- Biochemistry
- Peptide Research
Background:
- Leonuri Fructus is a traditional medicinal herb.
- Cyclic peptides possess diverse biological activities.
- Understanding peptide structure is crucial for their function.
Purpose of the Study:
- To isolate and characterize a novel cyclic peptide from Leonuri Fructus.
- To determine the amino acid sequence of the isolated cyclic peptide.
Main Methods:
- Isolation of the cyclic peptide from Leonuri Fructus.
- Mass spectroscopy for molecular weight determination.
- Protein sequencing of alpha-chymotrypsin partial hydrolysates.
Main Results:
- A cyclic peptide composed of twelve amino acid residues was successfully isolated.
- The complete amino acid sequence of the cyclic peptide was elucidated using combined analytical techniques.
Conclusions:
- The study successfully identified and sequenced a novel cyclic peptide from Leonuri Fructus.
- The established sequence provides a foundation for further investigation into the peptide's properties and potential applications.