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Related Concept Videos

What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jun 10, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
11:13

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Published on: June 9, 2023

Breast cancer.

Umberto Veronesi1, Aron Goldhirsch, Peter Boyle

  • 1European Institute of Oncology, Milan, Italy.

Discovery Medicine
|August 14, 2010
PubMed
Summary
This summary is machine-generated.

Breast cancer remains a global health concern. Declining mortality in some regions is linked to screening, diagnosis, and treatment advances, though incidence is rising in Japan.

Related Experiment Videos

Last Updated: Jun 10, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
11:13

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Published on: June 9, 2023

Area of Science:

  • Oncology
  • Public Health
  • Epidemiology

Background:

  • Breast cancer is a significant global public health issue, with over 1.15 million new cases diagnosed worldwide in 2002.
  • Mortality rates have declined in Western Europe, Australia, and the Americas since 1990, contrasting with rising rates in Japan.
  • While family history increases risk, the majority of breast cancer cases occur in women without a known family history.

Purpose of the Study:

  • To analyze global breast cancer incidence and mortality trends.
  • To identify factors contributing to declining mortality rates in specific regions.
  • To discuss the role of family history in breast cancer risk.

Main Methods:

  • Review of global breast cancer statistics and epidemiological data.
  • Analysis of trends in incidence and mortality rates across different countries.
  • Examination of risk factors, including family history.

Main Results:

  • Breast cancer incidence is high globally, with significant regional variations in mortality.
  • Declines in mortality are associated with improved mammographic screening, diagnostic accuracy, and treatment efficacy.
  • Women with first-degree relatives diagnosed with breast cancer have a higher lifetime incidence (5.5% with one relative, 13.3% with two).

Conclusions:

  • Advances in screening, diagnosis, and treatment have led to reduced breast cancer mortality in several Western countries.
  • Despite these advances, breast cancer remains a critical public health challenge, particularly with rising incidence in some populations.
  • While family history is a known risk factor, most breast cancer cases develop in individuals without a significant family history of the disease.