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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: Jun 10, 2026

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation
07:20

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation

Published on: January 14, 2011

Immunotherapy with enhanced self immune cells.

Mathias Oelke1, Jonathan Schneck

  • 1Departments of Pathology and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Discovery Medicine
|August 14, 2010
PubMed
Summary
This summary is machine-generated.

Adoptive immunotherapy, using engineered immune cells, offers a promising approach for treating cancers and viral infections. This therapy involves expanding a patient's own T cells ex vivo and reinfusing them for targeted treatment.

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Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles
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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

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Last Updated: Jun 10, 2026

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation
07:20

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation

Published on: January 14, 2011

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles
09:28

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Area of Science:

  • Immunology
  • Oncology
  • Infectious Diseases

Background:

  • Adoptive immunotherapy, or therapy with empowered self immune cells, has gained prominence in recent years.
  • This therapeutic strategy involves the ex vivo generation and expansion of antigen-specific T cells.

Purpose of the Study:

  • To review the current applications of adoptive immunotherapy.
  • To highlight its potential in treating viral infections and malignancies.

Main Methods:

  • Ex vivo generation and expansion of antigen-specific T cells.
  • Infusion of modified T cells back into patients.

Main Results:

  • Adoptive immunotherapy has shown promise in treating viral infections like cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human immunodeficiency virus (HIV).
  • It is also being evaluated for various cancers, including malignant melanoma and multiple myeloma.

Conclusions:

  • Adoptive immunotherapy represents a significant advancement in treating complex diseases.
  • Further research and clinical evaluation are ongoing to optimize its efficacy and expand its applications.