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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Videos

Supportive care in neurooncology.

Andrea Pace1, Giulio Metro, Alessandra Fabi

  • 1Division of Neurology, Regina Elena Cancer Institute, Rome, Italy. pace@ifo.it

Current Opinion in Oncology
|August 14, 2010
PubMed
Summary

Malignant brain tumors have a poor prognosis. This review highlights recent advances in managing brain tumor symptoms and palliative care, emphasizing the need for improved supportive and end-of-life care education.

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Area of Science:

  • Neuro-oncology
  • Palliative Care
  • Symptom Management

Background:

  • Malignant brain tumors present a poor prognosis with a short disease course, typically under one year.
  • Patients experience unique symptoms like peritumoral brain edema, venous thromboembolism, seizures, and infections, necessitating specialized supportive care.
  • Rehabilitation, psychological support, and end-of-life care decisions remain under-investigated areas in brain tumor management.

Purpose of the Study:

  • To review recent findings on managing key symptoms in brain tumor patients.
  • To discuss the complexities of palliative care for patients nearing the end of life.

Main Methods:

  • Literature review of recent studies on brain tumor symptom management.
  • Analysis of current palliative care strategies for advanced brain tumors.

Main Results:

  • Progress has been made in the medical management of brain tumor patients.
  • Effective management of symptoms such as brain edema, thromboembolism, seizures, and infections is crucial.
  • Palliative care discussions and end-of-life decision-making require further attention.

Conclusions:

  • While medical management has advanced, significant unmet needs persist in supportive and end-of-life care for brain tumor patients.
  • Enhanced education and research are vital for improving the quality of life and care for individuals with malignant brain tumors.