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Updated: Jun 10, 2026
09:36
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
[Acid-base disturbances in intensive-care patients]
Nils Smith-Erichsen1, Johan Kofstad, Baard Ingvaldsen
1Anestesiavdelingen, Oslo universitetssykehus, Ullevål, Norway. nils.smith-erichsen@vikenfiber.no
Summary
Acid-base disturbances in intensive care patients can lead to severe complications. A combined approach using standard base excess and albumin-corrected anion gap offers a reliable method for assessing acid-base status.
Area of Science:
- Critical care medicine
- Biochemistry
- Physiology
Context:
- Acid-base disturbances are common in intensive care units (ICUs).
- These disturbances can lead to multi-organ failure and impaired immune function.
- Understanding acid-base balance is crucial for managing critically ill patients.
Purpose:
- To provide an overview of acid-base disturbances in intensive care patients.
- To compare different methods of assessing acid-base status.
- To identify the most effective method for clinical practice.
Summary:
- The Henderson-Hasselbalch equation and standard base excess have limitations in fully describing acid-base status.
- The anion gap can help identify unmeasured anions but has associated uncertainties.
- The Stewart method, while comprehensive, is too complex for routine clinical use.
- A combination of standard base excess and albumin-corrected anion gap provides a practical and accurate assessment.
Impact:
- Improved understanding of acid-base balance in critical care.
- Guidance on selecting appropriate diagnostic tools for acid-base disturbances.
- Potential for better patient management and outcomes in ICUs.
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