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Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
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The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?

Italia Anna Asteriti1, Wilhelmina Maria Rensen, Catherine Lindon

  • 1Institute of Molecular Biology and Pathology, CNR, c/o Sapienza University of Rome, Via degli Apuli 4, 00185 Rome, Italy.

Biochimica Et Biophysica Acta
|August 17, 2010
PubMed
Summary

Aurora-A kinase, a target in cancer therapy, may require interaction with TPX2 to drive tumor cell transformation. Co-overexpression of Aurora-A and TPX2 suggests a novel oncogenic unit contributing to tumorigenesis.

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