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Updated: Jun 10, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Mouse phenotyping.

Helmut Fuchs1, Valérie Gailus-Durner, Thure Adler

  • 1Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 München/Neuherberg, Germany.

Methods (San Diego, Calif.)
|August 17, 2010
PubMed
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This summary is machine-generated.

Generating mutant mouse models aids in understanding human gene function. Comprehensive, standardized phenotyping is crucial for detecting subtle phenotypes, as exemplified by the German Mouse Clinic's approach.

Area of Science:

  • Genetics and Genomics
  • Developmental Biology
  • Translational Medicine

Background:

  • Mutant mouse lines are essential for studying human gene function and disease.
  • Various methods like ENU mutagenesis and gene editing generate models mimicking human conditions.
  • Pleiotropic gene effects necessitate thorough phenotyping to reveal all functions.

Purpose of the Study:

  • To highlight the importance of comprehensive phenotyping for mutant mouse models.
  • To introduce the German Mouse Clinic (GMC) as a key phenotyping platform.
  • To emphasize the role of standardized workflows in discovering hidden phenotypes.

Main Methods:

  • Generation of mutant mouse lines using techniques such as ENU mutagenesis, knock-out, knock-down, and knock-in.

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Last Updated: Jun 10, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

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Published on: April 23, 2015

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  • Comprehensive phenotyping of mutant mouse lines to detect diverse phenotypes.
  • Application of standardized phenotyping workflows, including EMPReSSslim.

    • Main Results:

    • The German Mouse Clinic (GMC) provides open access to advanced phenotyping services.
    • The GMC utilizes the European standard workflow EMPReSSslim for systemic phenotyping.
    • Standardized phenotyping enables the detection of phenotypes that might otherwise be missed.

    Conclusions:

    • Mutant mouse models are invaluable for human gene function research.
    • Systematic and standardized phenotyping is critical for maximizing the utility of mouse models.
    • The GMC serves as a vital resource for the scientific community in advancing mouse model research.