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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

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Correction: Adeluola et al. Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies. <i>Cancers</i> 2026, <i>18</i>, 1098.

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Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies.

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Related Experiment Video

Updated: Jun 10, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
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Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

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Cancer prevention with natural compounds.

Norleena P Gullett1, A R M Ruhul Amin, Soley Bayraktar

  • 1Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.

Seminars in Oncology
|August 17, 2010
PubMed
Summary

Naturally occurring phytochemicals from fruits and vegetables show promise for cancer prevention. These compounds are safe, affordable, and orally available, offering potential for cancer chemoprevention strategies.

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Area of Science:

  • Phytochemistry
  • Nutritional Science
  • Oncology

Background:

  • Botanical compounds have historical use in cancer treatment and prevention.
  • Population studies link high fruit and vegetable intake to reduced cancer risk.
  • Naturally occurring phytochemicals are of significant interest for cancer chemoprevention.

Purpose of the Study:

  • To review potential natural compounds for cancer prevention.
  • To discuss the mechanisms of action for these phytochemicals.

Main Methods:

  • Literature review of dietary botanicals and medicinal plants with reported cancer chemopreventive activity.
  • Identification of specific lead compounds currently in preclinical or clinical trials.

Main Results:

  • Numerous dietary botanicals, including cruciferous vegetables, Allium vegetables, green tea, citrus fruits, soybeans, tomatoes, berries, and ginger, exhibit cancer chemopreventive properties.
  • Key compounds like genistein, lycopene, brassinin, sulforaphane, indole-3-carbinol, and resveratrol are under investigation.
  • Phytochemicals offer advantages such as safety, low cost, and oral bioavailability.

Conclusions:

  • Phytochemicals present a promising avenue for cancer prevention due to their efficacy and favorable characteristics.
  • Further research into these natural compounds could lead to novel chemopreventive strategies.