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Role of c-Src in Carcinogenesis and Drug Resistance

Lukmon Raji1, Angelina Tetteh1, A R M Ruhul Amin1

  • 1Department of Pharmaceutical Sciences, Marshall University School of Pharmacy, Huntington, WV 25755, USA.

Cancers
|January 11, 2024
PubMed

Insights

The discovery of c-Src, a key protein in cancer development, reveals its role in activating multiple pathways driving cell growth and resistance to cancer therapies. Understanding c-Src is crucial for developing new cancer treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Carcinogenesis involves complex genetic and molecular alterations.
  • Src family kinases (SFK), including c-Src, are critical in cancer signaling.
  • c-Src activation promotes cell proliferation, survival, migration, invasion, metastasis, and drug resistance.

Purpose of the Study:

  • To review the discovery and structure of c-Src and v-Src.
  • To elucidate the molecular mechanisms of c-Src activation.
  • To detail signaling pathways regulated by c-Src in oncogenesis and drug resistance.

Main Methods:

  • Literature review of studies on c-Src and related signaling pathways.
  • Analysis of molecular mechanisms underlying c-Src activation and function.
  • Synthesis of information on c-Src's role in various cancers and treatment resistance.

Main Results:

  • c-Src's discovery provides insights into carcinogenesis.
  • Activated c-Src modulates key oncogenic pathways (PI3K-AKT, Ras-MAPK, JAK-STAT3, FAK/Paxillin).
  • c-Src contributes to cancer progression and resistance to therapies.

Conclusions:

  • c-Src is a significant oncogene with diverse roles in cancer.
  • Understanding c-Src's signaling network is vital for therapeutic strategies.
  • Targeting c-Src pathways may overcome drug resistance in cancer treatment.
Keywords:
c-Srccarcinogenesisdrug resistancesignal transductionv-Src

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