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Updated: Jun 10, 2026

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
Published on: December 14, 2014
Social play impairment following status epilepticus during early development
Adelisandra Silva Santos Castelhano1, Fulvio Alexandre Scorza, Maria Cristina Triguero Veloz Teixeira
1Programa de Pós-graduação em Distúrbios do Desenvolvimento, Laboratório de Neurobiologia, Universidade Presbiteriana Mackenzie (UPM), Rua da Consolação, 930. Prédio 38, CEP 01302-907 São Paulo, SP, Brazil.
Abstract:
Neonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the "intruder-resident" paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span.
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