Related Experiment Video
Updated: Jun 10, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Effect of bovine amniotic fluid on intra-abdominal adhesion in male rats
Abolghasem Esmaeili1, Behnam Abbasian, Hamidreza Kazemini
1Cell, Molecular & Developmental Division, Department of Biology, Faculty of Sciences, University of Isfahan, Hezar Jarib, Isfahan 8174673441, Iran. abesmaeili@yahoo.com
Background:
A wide variety of treatments have been proposed in order to deal with prevention of postoperative adhesions formation, but, no definitive results have been achieved. In the present study, bovine amniotic fluid (BAF) has been investigated as a possible option.
Materials And Methods:
84 male Wistar rats were undergone a laparotomy. After 2 weeks, adhesions were scaled grossly. Bovine amniotic fluid (in whole combination, without cells or without cells and proteins) extracted from cows carried either male or female calves was then applied to treated groups 2 weeks later during the second laparotomy. Adhesions were rescored 2 weeks later during a third laparotomy.
Results And Conclusion:
A significant reduction (P<0.05) in adhesions formation was observed only in rats treated with male bovine amniotic fluid without cells and proteins. Therefore, BAF could be used in treatment of adhesion formation because it is inexpensive, readily available, and has minimal side effects.
