Comparing endurance- and resistance-exercise training in people with multiple sclerosis: a randomized pilot study

Area of Science:

• Neurology
• Rehabilitation Medicine
• Exercise Science

Background:

• Multiple sclerosis (MS) is a chronic neurological disease impacting mobility and quality of life.
• Exercise interventions are crucial for managing MS symptoms and improving patient well-being.
• Comparing the effects of different exercise modalities is essential for optimizing rehabilitation strategies.

Purpose of the Study:

• To compare the adaptations in functional measures and quality of life following endurance versus resistance exercise training in individuals with multiple sclerosis (MS).

Main Methods:

• A randomized crossover design study involving 16 individuals with MS.
• Participants completed two 8-week supervised exercise programs (endurance and resistance) in a randomized order, separated by an 8-week washout period.
• Outcome measures included functional tests (grip strength, reach, gait, balance, endurance) and quality of life/symptom questionnaires.

Main Results:

• All 16 participants completed the study, attending a high percentage of prescribed exercise sessions.
• No significant adverse events were reported during either training program.
• No statistically significant differences were found in any functional or quality of life measures between the endurance and resistance exercise programs.

Conclusions:

• Both endurance and resistance exercise training are well-tolerated by individuals with MS.
• Current evidence suggests similar effects of both training types on functional outcomes and quality of life in MS.
• Larger-scale studies are needed to definitively confirm these comparable benefits and inform clinical recommendations.