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Updated: Jun 10, 2026

Cell Population Analyses During Skin Carcinogenesis

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Risk factors for single and multiple basal cell carcinomas.

Ville Kiiski¹, Esther de Vries, Sophie C Flohil

¹Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.

Archives of Dermatology

|August 18, 2010

Summary

Younger age at first basal cell carcinoma (BCC) diagnosis, red hair, higher socioeconomic status, and upper extremity lesions increase the risk of developing multiple BCC lesions. Closer follow-up is recommended for these patients.

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Area of Science:

Dermatology
Epidemiology
Oncology

Background:

Basal cell carcinoma (BCC) is the most common type of skin cancer.
Understanding the incidence of single versus multiple BCC lesions is crucial for patient management.
Identifying risk factors for multiple BCC development can inform preventative strategies.

Purpose of the Study:

To investigate the incidence of single and multiple basal cell carcinoma (BCC) lesions.
To identify associated risk factors for developing multiple BCC lesions.

Main Methods:

Prospective, population-based cohort study of 10,994 Dutch individuals aged 55 and older (1990-2007).
Data on BCC lesions collected from national pathology laboratories, hospitals, and general practices.
Multivariate logistic regression and Andersen-Gill models used to analyze associations between determinants and BCC lesion occurrence.

Main Results:

Of 10,820 eligible participants, 524 (4.8%) developed BCC, with 361 single and 163 (31.1%) multiple lesions.
Significant risk factors for a first BCC lesion included age and red hair.
Red hair, high educational level, and BCC location on upper extremities were associated with an increased risk of multiple lesions.

Conclusions:

Patients diagnosed with their first BCC at a younger age, those with red hair, higher socioeconomic status, or lesions on upper extremities face a higher risk of developing multiple BCCs.
These high-risk individuals warrant closer long-term follow-up.
Findings aid in risk stratification and personalized patient management for BCC.