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Elevated plasma osteopontin level is associated with pelvic inflammatory disease
Po-Hui Wang1, Yu-Fan Liu, Hsiu-Ting Tsai
1Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Reproductive Sciences (Thousand Oaks, Calif.)
|August 18, 2010
Summary
Elevated plasma osteopontin levels are associated with pelvic inflammatory disease (PID) and may serve as a predictive marker. Osteopontin gene variations did not show a significant link to PID risk in this study.
Area of Science:
- Biochemistry
- Genetics
- Reproductive Health
Background:
- Pelvic inflammatory disease (PID) is a significant gynecological infection.
- Biomarkers for PID diagnosis and risk assessment are crucial for effective management.
Purpose of the Study:
- To investigate the association between plasma osteopontin concentration, osteopontin gene single nucleotide polymorphisms (SNPs), and PID.
- To evaluate plasma osteopontin as a potential predictive marker for PID.
Main Methods:
- Plasma osteopontin levels were measured using enzyme-linked immunosorbent assay (ELISA).
- Osteopontin gene polymorphisms (rs1126616, rs9138) were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Main Results:
- Plasma osteopontin levels were significantly higher in PID patients than in healthy controls and decreased post-treatment.
- Osteopontin levels correlated with white blood cell (WBC) and neutrophil counts, and C-reactive protein (CRP) levels.
- No significant differences in osteopontin SNP genotypes or alleles were observed between PID patients and controls.
- A plasma osteopontin concentration of 58.53 ng/mL indicated an adjusted odds ratio of 3.87 for PID risk.
Conclusions:
- Plasma osteopontin concentration is elevated in PID and may serve as a predictive biomarker.
- Osteopontin gene polymorphisms (rs1126616, rs9138) are not associated with PID risk.
- Further research is warranted to validate osteopontin as a clinical predictor for PID.
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