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Related Concept Videos

Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Updated: Jun 10, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Solitary osteochondroma: spontaneous regression.

Alazne Valdivielso-Ortiz1, Ignasi Barber, Francisco Soldado

  • 1Radiology Department, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain.

Pediatric Radiology
|August 18, 2010
PubMed
Summary

Osteochondromas, common benign bone tumors, can rarely regress spontaneously. This case highlights a femur osteochondroma in a child that nearly disappeared over 4 years, influencing treatment decisions.

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Area of Science:

  • Orthopedics
  • Pediatric Oncology
  • Skeletal Dysplasias

Background:

  • Osteochondromas are the most frequent benign bone neoplasms, yet their etiology and pathogenesis remain unclear.
  • Spontaneous regression of osteochondromas is an exceptionally rare phenomenon.
  • Understanding the biological behavior of osteochondromas is crucial for effective clinical management.

Observation:

  • A case report details a 9-year-old female patient with a solitary osteochondroma located in the femur.
  • The osteochondroma exhibited significant spontaneous regression over a 4-year period.
  • Radiological follow-up confirmed near-complete resolution of the lesion.

Findings:

  • The study documents the remarkable spontaneous regression of a pediatric femoral osteochondroma.
  • This observation challenges the conventional understanding of osteochondroma's typically stable or progressive nature.
  • The case provides empirical evidence for the potential for complete resolution of these bone tumors.

Implications:

  • The findings suggest that observation, rather than immediate surgical intervention, may be a viable management strategy for select pediatric osteochondromas.
  • This case underscores the importance of considering spontaneous regression when formulating treatment plans for young patients with osteochondromas.
  • Further research into the mechanisms of osteochondroma regression could lead to novel therapeutic approaches.