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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Autoimmune Disorders01:29

Autoimmune Disorders

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Hepatitis01:25

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Viral Hepatitis I: Introduction01:28

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Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Chronic Pancreatitis II: Pathophysiology01:21

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Related Experiment Video

Updated: Jun 10, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

IL-17 contributes to autoimmune hepatitis.

Haijing Yu1, Jiaquan Huang, Yang Liu

  • 1Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. yhjmarry@hotmail.com

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
|August 18, 2010
PubMed
Summary
This summary is machine-generated.

Interleukin-17 (IL-17) drives autoimmune hepatitis (AIH) development. Neutralizing IL-17 reduced liver inflammation in AIH models, suggesting IL-17 as a potential therapeutic target for autoimmune hepatitis.

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Last Updated: Jun 10, 2026

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Area of Science:

  • Immunology
  • Hepatology
  • Autoimmune Diseases

Background:

  • Autoimmune hepatitis (AIH) is a chronic liver disease of unknown etiology.
  • Interleukin-17 (IL-17) is a pro-inflammatory cytokine implicated in various autoimmune conditions.

Purpose of the Study:

  • To investigate the role of IL-17 in the pathogenesis of autoimmune hepatitis (AIH).
  • To evaluate IL-17 as a potential therapeutic target for AIH.

Main Methods:

  • Established a mouse model of experimental autoimmune hepatitis (EAH) using S-100 antigen.
  • Measured IL-17 levels in serum and liver tissue via ELISA and immunohistochemistry.
  • Administered IL-17 neutralizing antibody in vivo to assess its therapeutic effect.
  • Quantified IL-17 expression in peripheral blood mononuclear cells (PBMCs) from AIH patients using real-time PCR.

Main Results:

  • IL-17 levels were significantly elevated in both AIH mouse models and human patients.
  • In vivo administration of IL-17 neutralizing antibody reduced hepatic inflammation and serum ALT levels in the EAH model.
  • PBMC IL-17 expression was notably higher in AIH patients compared to controls.

Conclusions:

  • IL-17 plays a significant role in promoting liver inflammation and disease progression in autoimmune hepatitis.
  • Targeting IL-17 with neutralizing antibodies demonstrates therapeutic potential for managing AIH.