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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Peptic Ulcer Disease II: Pathophysiology01:24

Peptic Ulcer Disease II: Pathophysiology

Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant use.Gastric UlcersGastric ulcers share...

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Related Experiment Video

Updated: Jun 10, 2026

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
04:48

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

[Corneal ulcers in systemic autoimmunologic diseases].

R Augsten1, J Dawczynski, U Voigt

  • 1Klinik für Augenheilkunde, Universitätsklinikum Jena, Bachstrasse 18, Jena. Regine.Augsten@med.uni-jena.de

Klinische Monatsblatter Fur Augenheilkunde
|August 18, 2010
PubMed
Summary
This summary is machine-generated.

Autoimmune diseases like rheumatoid arthritis can cause severe corneal ulcers, often leading to poor vision. Intensive treatment offers limited improvement, highlighting the need for lifelong immunosuppression to preserve sight.

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Corneal ulcers are a rare but severe complication of systemic autoimmune diseases.
  • Prognosis for these ulcers remains poor despite complex therapeutic interventions.

Observation:

  • A study cohort included seven patients (10 eyes) aged 45-73 with corneal ulcers, often perforated, linked to rheumatoid arthritis or Sjögren's syndrome.
  • Initial visual acuity varied significantly based on ulcer perforation status.

Findings:

  • Surgical interventions (conjunctival plasty, keratoplasty) combined with local and systemic immunosuppressive therapy were employed.
  • Despite treatment, visual acuity remained significantly impaired in eyes with perforated ulcers, with some cases requiring evisceration.
  • Eyes with non-perforated ulcers showed better visual outcomes with combined therapies.

Implications:

  • Corneal ulcers associated with autoimmune conditions pose a significant risk of vision loss, even with aggressive treatment.
  • Lifelong systemic immunosuppressive therapy is crucial for managing these conditions and preserving vision in the affected eye.