Related Experiment Video
Updated: Jun 10, 2026
09:35
Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
Published on: May 1, 2012
Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach
1Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Ontario, Canada, K1A 0R6. Danxia.Xu@Nrc-cnrc.gc.ca
Optics Letters
|August 19, 2010
Summary
We developed a silicon biosensor array for simultaneous molecular binding detection. This device offers high sensitivity and stability for real-time biomolecule monitoring.
Area of Science:
- Photonics
- Biosensing
- Nanotechnology
Background:
- Label-free biosensing is crucial for real-time molecular interaction analysis.
- Silicon photonics offers a scalable platform for integrated optical devices.
Purpose of the Study:
- To demonstrate a silicon-on-insulator ring resonator biosensor array.
- To achieve simultaneous monitoring of multiplexed molecular bindings with high sensitivity and stability.
Main Methods:
- Utilized a silicon-on-insulator platform with a ring resonator array.
- Employed wavelength division multiplexing for addressing.
- Implemented on-chip referencing for environmental drift cancellation.
Main Results:
- Achieved simultaneous monitoring of multiplexed molecular bindings.
- Demonstrated a resolution of 0.3 pg/mm² (40 ag total mass).
- Detected protein concentrations over 4 orders of magnitude down to 20 pM with high stability over 3 hours.
Conclusions:
- The developed biosensor array enables sensitive and stable multiplexed biomolecular detection.
- On-chip referencing effectively cancels environmental drift.
- This technology holds promise for various diagnostic and research applications.
