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Updated: Jun 10, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic properties
Fabien Accadbled1, Bernard Tinant, Eric Hénon
1Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, Université de Reims Champagne-Ardenne, BP 1039, 51687, Reims Cedex, France.
Abstract:
Original palladium complexes involving (-)-ephedrine, (-)-norephedrine, L-prolinol, L-valinol and L-isoleucinol have been rapidly prepared in neutral or basic medium and simply purified. They have been fully characterized by classical analytical methods and four of them were characterized by X-Ray analysis. In parallel with the experimental work, HF-DFT(B3LYP/PCM) computations were performed to obtain additional structural information. Their antiproliferative properties have been evaluated and some complexes showed small activities especially towards HT29 human cancer cells.
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