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Published on: November 4, 2010
Occupational asthma caused by triglycidyl isocyanurate
Joaquín Sastre1, Jerónimo Carnes, Manuela García del Potro
1Allergy Department, Fundación Jiménez Díaz-Capio and CIBER de Enfermedades Respiratorias (CIBERES), Av. Reyes Católicos 2, 28040 Madrid, Spain. jsastre@fjd.es
International Archives of Occupational and Environmental Health
|August 19, 2010
Summary
Occupational asthma was triggered by inhaling triglycidyl isocyanurate (TGIC) powder paint in a factory worker. This study confirms TGIC as an allergen causing immunologic occupational asthma, even without an IgE mechanism.
Area of Science:
- Occupational Medicine
- Toxicology
- Immunology
Background:
- Triglycidyl isocyanurate (TGIC) is used in polyester powder paints.
- Previous reports link TGIC to allergic contact dermatitis, occupational asthma, and hypersensitivity pneumonitis in painters.
Observation:
- A 28-year-old female powder-coating factory worker developed asthma-like symptoms after 4 months.
- Symptoms correlated with work periods, showing significant peak-flow variability (up to 46%) and methacholine test variations.
Findings:
- Controlled exposure to TGIC (3.61 mg/m³) induced a 20% fall in FEV1, cough, and wheezing within 15 minutes.
- No IgE antibodies were detected, suggesting a non-IgE mediated immunologic response.
- Bronchial hyperresponsiveness and fractional exhaled nitric oxide (FENO) levels did not change 24 hours post-challenge.
Implications:
- TGIC inhalation is confirmed as a cause of immunologic occupational asthma.
- The findings highlight the need for workplace safety measures to prevent TGIC exposure.
- Further research may be needed to elucidate the exact immunologic pathway involved in TGIC-induced asthma.
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