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Postinfectious bronchiolitis obliterans in children: clinical and pulmonary function findings

V Aguerre1, C Castaños, H Gonzalez Pena

  • 1Pulmonology Department, Hospital de Pediatria Dr Juan P Garrahan, Buenos Aires, Argentina. vaguerre@garrahan.gov.ar

Pediatric Pulmonology
|August 19, 2010
PubMed

Insights

Postinfectious bronchiolitis obliterans (PIBO) in children, often linked to Adenovirus (Ad), causes severe lung disease. This study found no significant differences in clinical or pulmonary function outcomes between Ad-positive and unidentified cases.

Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases
  • Respiratory Medicine

Background:

  • Postinfectious bronchiolitis obliterans (PIBO) is a severe, uncommon lung condition in children following acute lower respiratory infection (ALRI).
  • Adenovirus (Ad) is a frequent cause of PIBO in infants and young children.
  • Understanding PIBO's clinical course and pulmonary function is crucial for management.

Purpose of the Study:

  • To analyze the clinical features and pulmonary function in children diagnosed with PIBO.
  • To compare PIBO cases associated with Adenovirus (Ad) to those with no identified viral agent.

Main Methods:

  • A prospective study of 58 children with PIBO.
  • Evaluation of clinical data and pulmonary function tests (spirometry and plethysmography).
  • Patients were categorized into two groups: Adenovirus positive (G1) and no identified etiologic agent.

Main Results:

  • The study included 58 patients (3.4:1 male/female ratio) with a median age of 8 years; mean age at initial injury was 11 months.
  • Pulmonary function tests revealed significant obstructive patterns: FVC 68±13%, FEV1 40.5±11%, FMMF(25-75%) 16.7±7.5%.
  • No statistically significant differences in clinical, spirometric, or plethysmographic data were observed between the Adenovirus-positive group and the group with no identified agent.

Conclusions:

  • PIBO is a debilitating pediatric lung disease characterized by a significant obstructive pattern on pulmonary function tests.
  • Both groups, Adenovirus-positive and those with unidentified causes, exhibited similar acute-phase characteristics and severity of long-term lung damage.
Abstract

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