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Related Concept Videos

Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

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Related Experiment Video

Updated: Jun 10, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

The Forkhead factor FoxQ1 influences epithelial differentiation.

A Feuerborn1, P K Srivastava, S Küffer

  • 1Department of Cellular and Molecular Pathology, German Cancer Research Centre (DKFZ), Heidelberg, Germany. a.feuerborn@dkfz-heidelberg.de

Journal of Cellular Physiology
|August 19, 2010
PubMed
Summary
This summary is machine-generated.

The transcription factor FoxQ1 plays a key role in epithelial plasticity and differentiation. Repressing FoxQ1 impacts cell morphology, cell cycle, and migration, mediating TGF-β1 effects.

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Last Updated: Jun 10, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
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Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue
17:38

Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue

Published on: April 27, 2012

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • The Forkhead family of transcription factors regulates critical cellular processes.
  • Epithelial plasticity is crucial for development and disease.
  • Transforming growth factor-beta 1 (TGF-β1) influences epithelial cell behavior.

Purpose of the Study:

  • To investigate the role of the Forkhead factor FoxQ1 in epithelial differentiation and plasticity.
  • To elucidate FoxQ1's function in mammary epithelial cells.
  • To determine FoxQ1's involvement in TGF-β1-induced cellular changes.

Main Methods:

  • Identifying FoxQ1 expression changes during TGF-β1 treatment.
  • Repressing FoxQ1 expression in mammary epithelial cells (knock-down).
  • Analyzing cell morphology, junction protein expression (e.g., E-cadherin), actin cytoskeleton, cell cycle progression, and migratory capacity.
  • Performing gene expression profiling (NM18 cells).

Main Results:

  • FoxQ1 expression increased during TGF-β1-induced epithelial differentiation.
  • FoxQ1 repression altered cell morphology, increased cell size, cell-cell contacts, and E-cadherin expression.
  • FoxQ1 knock-down resulted in actin cytoskeleton rearrangements, slower G1-phase progression, and enhanced cell migration.
  • FoxQ1 was identified as a downstream mediator of TGF-β1-induced gene expression changes, including factors like Ets-1, Zeb1, and Zeb2.

Conclusions:

  • FoxQ1 is a significant regulator of epithelial plasticity and differentiation.
  • FoxQ1 mediates key aspects of TGF-β1 signaling in epithelial cells.
  • Understanding FoxQ1's function provides insights into epithelial cell behavior and potential therapeutic targets.