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Ibuprofen and acute kidney injury in the newborn

Vassilios Fanos1, Roberto Antonucci, Marco Zaffanello

  • 1Section of Neonatal Intensive Care Unit, Department of Pediatrics and Clinical Medicine, University of Cagliari, Cagliari, Italy.

The Turkish Journal of Pediatrics
|August 20, 2010
PubMed

Insights

Ibuprofen is a viable alternative to indomethacin for treating patent ductus arteriosus (PDA) in preterm infants. Its comparable effectiveness and favorable renal tolerability support its routine use in neonatal care.

Area of Science:

  • Neonatal pharmacology
  • Pediatric cardiology

Background:

  • Patent ductus arteriosus (PDA) treatment in preterm infants is debated, focusing on drug choice (ibuprofen vs. indomethacin) and timing.
  • Indomethacin has historically been the preferred medication for PDA closure.
  • Ibuprofen lysine gained FDA approval in 2006 for PDA treatment in specific premature infants.

Purpose of the Study:

  • To review the pharmacological treatment options for PDA in preterm neonates.
  • To discuss the effects of ibuprofen on neonatal renal function.
  • To highlight ibuprofen's renal tolerability as a key factor for its routine use.

Main Methods:

  • Review of existing knowledge on ibuprofen and indomethacin for PDA treatment.
  • Focus on studies evaluating renal function in neonates treated with ibuprofen.
  • Analysis of comparative effectiveness and safety profiles.

Main Results:

  • Ibuprofen demonstrates comparable effectiveness to indomethacin in closing PDA.
  • Ibuprofen exhibits good renal tolerability in preterm infants.
  • This favorable renal profile is a significant advantage for ibuprofen.

Conclusions:

  • Ibuprofen is a well-tolerated and effective alternative for PDA pharmacological treatment in preterm infants.
  • Its established renal safety supports its consideration for routine clinical practice.
  • Further research may solidify ibuprofen's role in managing PDA.

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