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Related Concept Videos

Vascular Resistance01:20

Vascular Resistance

Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Related Experiment Video

Updated: Jun 10, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Endothelial function and hemodynamics in systemic sclerosis.

Pascal Rossi1, Brigitte Granel, Dominique Marziale

  • 1Internal Medicine department, North Hospital, Chemin des Bourrely, Marseille Cedex, France. lt16@bbh.regionh.dk

Clinical Physiology and Functional Imaging
|August 20, 2010
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis impairs endothelial function, affecting blood vessel dilation independently of systemic arterial compliance. Pulmonary artery pressure and small artery involvement significantly impact this endothelial dysfunction in SSc patients.

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Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
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Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Related Experiment Videos

Last Updated: Jun 10, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
06:35

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Area of Science:

  • Cardiovascular Research
  • Rheumatology
  • Vascular Biology

Background:

  • Systemic sclerosis (SSc) is a fibrotic disease impacting skin and organs, linked to vascular damage.
  • Key parameters influencing vascular damage in SSc remain underexplored.

Purpose of the Study:

  • To investigate endothelial function in SSc patients.
  • To determine the relationship between endothelial function, pulmonary artery pressure, and systemic arterial compliance (SAC).

Main Methods:

  • Studied 14 SSc females and 14 matched healthy controls.
  • Measured brachial artery flow-mediated dilation (FMD) and nitroglycerin-induced dilation (NMD).
  • Assessed SAC, cardiac output, systemic arterial resistance, and pulmonary artery pressure using echocardiography Doppler.

Main Results:

  • SSc patients exhibited significantly reduced FMD and NMD compared to controls.
  • Post-ischaemic reactive hyperaemia was lower in SSc patients.
  • FMD and NMD correlated with cardiac output; FMD correlated with pulmonary artery pressure and peripheral resistance.

Conclusions:

  • Endothelial function is impaired in SSc, independent of SAC.
  • Small artery and pulmonary artery involvement severity influences endothelium-dependent function in SSc.