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Updated: Jun 10, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

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[Identification and Functional Analysis of A Novel Candidate Oncogene RAP2B in Lung Cancer.]

Guobin Fu1, Yan Liu, Jinsong Yuan

  • 1Department of Etiology and Carcinogenesis, Cancer Institute (Hosptial), Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100021, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|August 20, 2010
PubMed
Abstract

Insights

RAP2B, a novel gene in lung cancer, promotes cell transformation and activates the NF-kappaB pathway, suggesting its role as an oncogene in carcinogenesis.

Area of Science:

  • Molecular biology
  • Oncology
  • Gene expression analysis

Context:

  • RAP2B is a novel candidate gene identified in lung cancer.
  • Its function in carcinogenesis remains largely unknown.
  • Belongs to the Ras superfamily with a conserved domain.

Purpose:

  • To investigate the role of RAP2B in carcinogenesis.
  • To explore the potential of RAP2B as a cancer-related gene.

Summary:

  • RT-PCR revealed elevated RAP2B mRNA in 67% of lung squamous cell carcinoma tissues compared to adjacent normal tissues.
  • RAP2B transfection induced transformation in Rat1 cells.
  • Reporter gene assays demonstrated RAP2B activates the NF-kappaB pathway over 3-fold.

Impact:

  • RAP2B may function as an oncogene in lung cancer development.
  • Activation of the NF-kappaB pathway by RAP2B is a key mechanism.
  • Provides a potential therapeutic target for lung cancer.

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