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Published on: March 27, 2026
[Pylephlebitis in the child: a challenging diagnosis].
M-E Gatibelza1, J Gaudin, J Mcheik
1Service médicochirurgical de pédiatrie, CHU de Poitiers, BP 577, 2, rue de la Milétrie, 86021 Poitiers cedex, France. Marie-eve.gatibelza@wanadoo.fr
Pylephlebitis, a rare septic thrombophlebitis of the portomesenteric veins, can follow undiagnosed appendicitis in children. Early diagnosis via CT scan and prompt treatment, including appendectomy and antibiotics, leads to favorable outcomes.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Vascular Surgery
Background:
- Pylephlebitis, or septic thrombophlebitis of the portomesenteric veins, is a rare but serious complication of intra-abdominal infections.
- Diagnosis in children is often delayed due to non-specific symptoms and normal physical examinations.
- Appendicitis is a common underlying cause, particularly when clinically subacute or retrocecal.
Observation:
- Two pediatric cases of pylephlebitis secondary to undiagnosed appendicitis are presented.
- One patient was initially misdiagnosed with Salmonella infection, highlighting diagnostic challenges.
- Computed tomography (CT) scans were crucial for accurate diagnosis in both cases.
Findings:
- Both children recovered satisfactorily after appendectomy, long-term antibiotic therapy, and anticoagulation.
- CT imaging is the preferred diagnostic modality, identifying pylephlebitis and its intra-abdominal source.
- Doppler sonography is valuable for monitoring portal vein thrombosis progression.
Implications:
- Prompt diagnosis and management of pylephlebitis, especially in pediatric cases of appendicitis, are essential for preventing complications.
- While anticoagulation in children remains debated, early initiation is often recommended to improve portal vein flow.
- Raising awareness of pylephlebitis as a complication of appendicitis can reduce diagnostic delays and improve patient outcomes.
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