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An age-related decrease in factor V Leiden frequency among Polish subjects.

G Adler1, M Parczewski, E Czerska

  • 1Department of Laboratory Diagnostics & Molecular Medicine, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland. gra2@op.pl

Journal of Applied Genetics
|August 20, 2010
PubMed
Summary

Factor V Leiden (G1691A FV mutation) is linked to deep vein thrombosis. This study found the G1691A mutation is less common in long-lived Poles, suggesting it may reduce lifespan.

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Area of Science:

  • Genetics
  • Evolutionary Biology
  • Gerontology

Background:

  • Factor V Leiden (G1691A FV mutation) is a known risk factor for deep vein thrombosis and pulmonary embolism.
  • Its high prevalence suggests a potential evolutionary advantage, possibly related to survival benefits in certain conditions.
  • The hypothesis of a favorable association between the G1691A mutation and longevity requires investigation.

Purpose of the Study:

  • To investigate the association between the G1691A factor V Leiden mutation and longevity in the Polish population.
  • To determine if the A1691 allele confers a survival advantage or disadvantage.

Main Methods:

  • Genotyping for the G1691A factor V Leiden mutation using PCR-RFLP.
  • Analysis of mutation and allele frequencies in three distinct Polish cohorts: neonates, healthy adults, and long-lived individuals (≥95 years).
  • Statistical comparison of mutation carrier rates across age groups.

Main Results:

  • The frequency of G1691A carriers and the A1691 allele was significantly lower in long-lived individuals (0.2% and 0.1%) compared to neonates (4.2% and 2.2%) and adults (3.3% and 1.6%).
  • A decrease in the frequency of the G1691A factor V Leiden mutation was observed with increasing age.
  • These findings indicate a potential negative impact of the A1691 allele on survival time in the studied population.

Conclusions:

  • The G1691A factor V Leiden mutation is associated with reduced longevity in the Polish population.
  • The hypothesis of a favorable association between the A1691 allele and longevity is contradicted by this study.
  • The observed decrease in mutation frequency with age suggests a potential survival disadvantage for carriers.