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Updated: Jun 10, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Autoimmune bullous skin diseases occurring under anti-tumor necrosis factor therapy: two case reports
L Boussemart1, S Jacobelli, F Batteux
1Department of Dermatology and Venereology, Hôpital Cochin, Paris, France.
Background:
Anti-tumor necrosis factor (TNF) agents are increasingly being used for a rapidly expanding number of rheumatic and systemic diseases. As a result of this use, and of the longer follow-up periods of treatment, there are a growing number of reports of the development of autoimmune processes related to anti-TNF agents. The use of anti-TNF agents has been associated with more and more cases of autoimmune diseases, principally cutaneous vasculitis, lupus-like syndrome, systemic lupus erythematosus and interstitial lung disease.
Observations:
We report 2 cases of autoimmune bullous skin disease occurring in patients undergoing TNF-targeted therapy: a bullous pemphigoid and a pemphigus foliaceus. Both patients were treated by anti-TNF agents for rheumatoid arthritis and showed improvement following interruption of that treatment. Here, we discuss the relationship between anti-TNF therapy and the occurrence of autoimmune bullous disease.
Conclusion:
Anti-TNF agents should be considered as a potential cause of drug-induced autoimmune bullous skin disease.
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