Related Experiment Video
Updated: Jun 10, 2026
11:27
Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
Published on: April 29, 2014
Paraneoplastic glomerulopathy secondary to retroperitoneal sarcoma: a case report
Jingjing L Sherman1, Eric Y Liu, Junko Ozao-Choy
1Division of General Surgery, Department of Surgery, The Mount Sinai Hospital, New York, New York, USA.
Journal of Surgical Oncology
|August 20, 2010
Summary
This study reports a rare case of paraneoplastic glomerulopathy, a kidney disorder linked to cancer, caused by a retroperitoneal sarcoma. Treatment with steroids led to remission of the patient's nephrotic syndrome.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Glomerulopathy can manifest as a rare paraneoplastic syndrome.
- Retroperitoneal sarcomas are malignant tumors originating in the abdominal cavity.
Observation:
- A patient presented with generalized edema and nephrotic syndrome.
- Imaging revealed two large retroperitoneal masses, one of which was surgically resected.
Findings:
- Post-resection, the patient experienced kidney failure.
- Kidney biopsy confirmed minimal change disease.
- Steroid therapy resulted in remission of nephrotic symptoms.
Implications:
- This case highlights minimal change disease as a potential manifestation of paraneoplastic glomerulopathy.
- The proposed mechanism involves cytokine-induced damage from a T-cell response to malignancy.
- Further research into paraneoplastic syndromes and their renal manifestations is warranted.
