Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Symbiosis00:58

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infants under 24 months with severe malaria have a serological profile of active infection with Epstein Barr Virus.

The Journal of infectious diseases·2026
Same author

Asymptomatic Plasmodium falciparum Infection Was Not Associated with Exposure to Soil-Transmitted Helminths in Children in Esse, Cameroon.

The American journal of tropical medicine and hygiene·2026
Same author

A Comparison of Flow Cytometry-based versus ImmunoSpot- or Supernatant-based Detection of SARS-CoV-2 Spike-specific Memory B Cells in Peripheral Blood.

Vaccines·2026
Same author

SARS-CoV-2 Infection or COVID-19 mRNA Vaccination Elicits Partially Different Spike-Reactive Memory B Cell Responses in Naïve Individuals.

Vaccines·2025
Same author

Pericytes: The forgotten controllers of a functional blood-brain barrier.

PLoS pathogens·2025
Same author

Acute Epstein Barr Virus is a risk factor for severe malaria in infants under 24 months.

medRxiv : the preprint server for health sciences·2025
Same journal

Applications of lupeol to manage fungal infections: a promising multi-target molecule.

Future microbiology·2026
Same journal

Benzyl isothiocyanate-loaded chitosan beads: a novel strategy to combat biofilm formation by <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>.

Future microbiology·2026
Same journal

<i>Mycobacterium colombiense</i> isolation among people living with human immunodeficiency virus: a case series.

Future microbiology·2026
Same journal

Thwarting the biothreat in the 21st century: means and methods.

Future microbiology·2026
Same journal

The oral-respiratory interface: modulation of <i>Streptococcus pneumoniae</i> serotype adhesion by the periodontal pathogen <i>Porphyromonas gingivalis</i> W83.

Future microbiology·2026
Same journal

Global One Health genomics identify conserved virulence and mobile resistance in the opportunistic pathogen <i>Staphylococcus saprophyticus</i>.

Future microbiology·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

How do malaria parasites activate dendritic cells?

Tracey J Lamb1, Michael P Schenk, Stephen M Todryk

  • 1School of Biological Sciences, Hopkins Building, University of Reading, Whiteknights Campus, Reading RG66UB, UK. t.j.lamb@reading.ac.uk

Future Microbiology
|August 21, 2010
PubMed
Summary
This summary is machine-generated.

Malaria parasites activate immune cells through a specific protein-DNA complex. This finding reveals a key trigger for the innate immune response to malaria infection.

More Related Videos

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice
12:48

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice

Published on: January 2, 2013

Evaluation of Extracellular Vesicle Function During Malaria Infection
13:45

Evaluation of Extracellular Vesicle Function During Malaria Infection

Published on: February 14, 2018

Related Experiment Videos

Last Updated: Jun 10, 2026

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice
12:48

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice

Published on: January 2, 2013

Evaluation of Extracellular Vesicle Function During Malaria Infection
13:45

Evaluation of Extracellular Vesicle Function During Malaria Infection

Published on: February 14, 2018

Area of Science:

  • Immunology
  • Infectious Diseases
  • Parasitology

Background:

  • Malaria parasites trigger strong immune responses, involving CD4+ Th1 cells and dendritic cells (DCs).
  • DCs secrete IL-12 to activate Th1 cells, crucial for controlling malaria parasitemia but also linked to pathology.
  • The specific components of malaria-infected red blood cells that activate DCs remain largely unidentified.

Discussion:

  • This study aimed to pinpoint the malaria-derived molecules responsible for DC activation and subsequent cytokine production (IL-12 and TNF-alpha).
  • Researchers deconstructed malaria-infected red blood cells to isolate and test immunogenic components.
  • The findings implicate a specific complex of parasite DNA and protein as the primary activator of DCs.

Key Insights:

  • A protein-DNA complex derived from the malaria parasite is identified as the exclusive component that activates dendritic cells.
  • This complex effectively triggers innate immune responses, including the secretion of IL-12 and TNF-alpha by DCs.
  • Understanding this specific trigger is vital for comprehending malaria's immunopathology and developing targeted interventions.

Outlook:

  • Further research can explore the precise structure and function of this protein-DNA complex.
  • This knowledge may lead to novel therapeutic strategies or vaccines targeting malaria-induced inflammation.
  • Investigating how other parasitic components interact with or are modulated by this complex could offer deeper insights.