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Updated: Jun 10, 2026
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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
CD47 in xenograft rejection and tolerance induction
1Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. yy2324@columbia.edu
Xenotransplantation
|August 21, 2010
Summary
Xenotransplantation faces immune rejection due to genetic differences. This review explores CD47, a molecule that may help overcome immune barriers and induce tolerance for xenografts.
Area of Science:
- Immunology
- Transplantation Science
- Molecular Biology
Background:
- Xenotransplantation offers a solution to organ shortages but faces robust immune rejection.
- Genetic disparities between donor and recipient drive intense xenograft rejection compared to allografts.
- Xenografts trigger host immunity via xenoantigens and lack ligands for inhibitory receptors.
Purpose of the Study:
- To review recent findings on the role of CD47 in xenograft rejection.
- To investigate the potential of CD47 in inducing xenotolerance for transplantation.
Main Methods:
- Literature review of recent studies on CD47 and SIRPalpha interactions.
- Analysis of mechanisms underlying xenograft rejection and tolerance induction.
- Focus on the role of CD47 as a ligand for the SIRPalpha inhibitory receptor.
Main Results:
- CD47 plays a critical role in modulating host immune responses to xenografts.
- Dysregulation of CD47-SIRPalpha signaling contributes to xenograft rejection.
- Targeting CD47 may offer a strategy to enhance xenograft survival and promote tolerance.
Conclusions:
- CD47 is a key factor in xenograft rejection and a potential target for therapeutic intervention.
- Modulating CD47-SIRPalpha interactions could be crucial for successful xenotransplantation.
- Further research into CD47 is essential for advancing xenotransplantation as a clinical option.
