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Related Concept Videos

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Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Updated: Jun 10, 2026

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Arthritis in leprosy.

Sandeep Chauhan1, Anupam Wakhlu, Vikas Agarwal

  • 1Nobles Hospital, Isle of Man, UK.

Rheumatology (Oxford, England)
|August 21, 2010
PubMed
Summary
This summary is machine-generated.

Leprosy, a bacterial infection, often affects skin and nerves but commonly involves joints and muscles. Recognizing these musculoskeletal signs is crucial for timely diagnosis and preventing deformities.

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Last Updated: Jun 10, 2026

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Dermatology

Background:

  • Leprosy, caused by Mycobacterium leprae, classically presents with skin and nerve issues.
  • Musculoskeletal involvement is common but often underdiagnosed, presenting diverse rheumatological symptoms.
  • Increasing global travel necessitates awareness of leprosy's varied manifestations in non-endemic areas.

Purpose of the Study:

  • To provide a comprehensive overview of rheumatological manifestations of leprosy.
  • To increase awareness among rheumatologists and physicians regarding leprosy's musculoskeletal impact.
  • To highlight the importance of early diagnosis and management to prevent deformities.

Main Methods:

  • This is a review article.
  • It synthesizes clinical information on leprosy's rheumatological presentations.
  • It discusses various musculoskeletal conditions associated with leprosy.

Main Results:

  • Musculoskeletal involvement in leprosy includes Charcot's arthropathy, polyarthritis, tenosynovitis, and enthesitis.
  • Articular symptoms can be the sole presentation, even without skin lesions.
  • Leprosy should be considered in patients with unexplained rheumatological symptoms, especially those with travel history or on immunosuppressants like anti-TNF-α therapy.

Conclusions:

  • Rheumatologists must be aware of the diverse rheumatological manifestations of leprosy.
  • Early recognition and treatment of leprosy are vital to prevent irreversible joint damage and functional loss.
  • Familiarity with leprosy's rheumatological spectrum is essential for global health professionals.