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Cholelithiasis in hepatic cirrhosis: evaluating the role of risk factors

Zamir Butt1, Qurratulain Hyder

  • 1Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan.

JPMA. the Journal of the Pakistan Medical Association
|August 24, 2010
PubMed

Insights

Gallstones are common in patients with advanced Hepatic Cirrhosis (HC). Risk factors like older age, longer disease duration, and ascites significantly increase gallstone prevalence in these patients.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Radiology

Background:

  • Hepatic Cirrhosis (HC) is a significant health concern.
  • Cholelithiasis (gallstones) prevalence and risk factors in HC patients require further investigation.

Purpose of the Study:

  • To identify and analyze risk factors associated with cholelithiasis in patients diagnosed with Hepatic Cirrhosis.

Main Methods:

  • A prospective study involving 206 advanced HC patients and a control group.
  • Conventional ultrasound was utilized to detect gallstones and assess related parameters.
  • Exclusion criteria included prior cholecystectomy and diabetes mellitus.

Main Results:

  • Hepatitis C Virus (HCV) was the primary cause of HC in 90.88% of cases.
  • Gallstones were detected in 24.30% of patients, with a higher incidence in males.
  • Significant correlations were found between gallstones and advanced age, prolonged HC duration, Child-Pugh class C, gallbladder wall thickening, ascites, splenic enlargement, and increased portal vein diameter (p < 0.001).

Conclusions:

  • Decompensated Chronic Liver Disease (CLD) presents a higher frequency of gallstones.
  • Multiple interacting risk factors contribute to the increased occurrence of gallstones in HC patients.
Abstract

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