Related Experiment Video
Updated: Jun 10, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
[Functional interplay of dopamine D1 and D2 receptors in the immune response control in different psychoemotional
Abstract:
It is established that preliminary blockade ofdopamine (DA) D2 receptors with haloperidol prevents immunostimulation observed upon the activation of D1 receptors with selective agonist SKF 38393 in mice of the CBA and C57BL/6J strains having no experience in social confrontations. These data are indicative of the functional interconnection between DA receptors of the D1 and D2 subtypes in the immune response control. Similar link between these DA receptor subtypes has been also found in C57BL/6J mice conditioned to display aggressive or submissive behaviors during 10-day social encounter testing. The data obtained give evidence that the interaction between D1 and D2 receptors is manifested in animals with various genotypes and psychoemotional states.
Related Concept Videos
Physiology of Emotion
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...
The Two-State Receptor Model
The binding affinity of a drug determines its interaction with one...
Neurotransmitters
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Drugs Affecting Neurotransmitter Synthesis
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...

