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A new HLA-B*15 variant, B*15:144, identified by sequence-based typing in a Chinese individual

L Dong1, L-N Yan, J-H Xie

  • 1Tissue Typing Lab, Tianjin Blood Center, Tianjin, China.

Tissue Antigens
|August 24, 2010
PubMed

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...