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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

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Published on: April 12, 2021

Medication-related problems in CKD.

Katie E Cardone¹, Shaffeeulah Bacchus, Magdalene M Assimon

¹Albany College of Pharmacy and Health Sciences, NY, USA.

Advances in Chronic Kidney Disease

|August 24, 2010

Summary

This summary is machine-generated.

Patients with chronic kidney disease (CKD) face complex medication regimens, increasing risks of medication-related problems (MRPs). This review explores MRP prevalence, impact, and clinical strategies for mitigation.

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Area of Science:

Nephrology
Clinical Pharmacy
Pharmacovigilance

Background:

Patients with chronic kidney disease (CKD) are frequently prescribed multiple medications for comorbidities and disease management.
Declining kidney function often necessitates increased medication complexity, elevating the risk of medication-related problems (MRPs).
MRPs are linked to adverse health outcomes, including increased morbidity, mortality, and reduced quality of life.

Purpose of the Study:

To review the prevalence and impact of medication-related problems (MRPs) in patients with chronic kidney disease (CKD).
To identify and summarize clinical strategies for reducing and resolving MRPs in this vulnerable population.

Main Methods:

Systematic literature review of studies reporting on medication use, MRPs, and management strategies in CKD patients.
Analysis of data on the prevalence, types, and consequences of MRPs in the CKD population.
Synthesis of evidence-based clinical interventions aimed at mitigating MRPs.

Main Results:

Complex polypharmacy is common in CKD, significantly increasing the likelihood of MRPs.
MRPs in CKD are associated with substantial increases in healthcare utilization and adverse clinical outcomes.
Various clinical interventions, including medication reviews and patient education, show promise in reducing MRPs.

Conclusions:

Addressing medication complexity and preventing MRPs is crucial for improving outcomes in chronic kidney disease (CKD) patients.
Proactive clinical strategies are essential for managing polypharmacy and minimizing the risks associated with MRPs in CKD.
Further research into optimized medication management protocols for CKD is warranted.