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The physiological significance of p27(KIP1) expression in detrusor function

Robert A Niederhoff1, Scott R Manson, Ahmad Tawfik

  • 1Division of Pediatric Urology, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri, USA.

The Journal of Urology
|August 24, 2010
PubMed
Summary

The cyclin-dependent kinase inhibitor p27(KIP1) is crucial for maintaining normal bladder function. Loss of p27(KIP1) leads to smooth muscle cell hyperplasia and reduced bladder capacity and compliance.

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